Grapefruit with Your Statin?
نویسندگان
چکیده
منابع مشابه
Some Salt with Your Statin, Professor?
We know that clinical trials sponsored by the pharmaceutical industry are likely to exaggerate benefit and minimise harms. But do these biases extend to their sponsorship of non-human animal research? Using systematic review and meta-analysis Bero and colleagues show that, in the case of statins, things are a little more complicated. While the conclusions of industry-sponsored studies were inde...
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The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
متن کاملManagement of grapefruit-drug interactions.
Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism through the intestinal cytochrome P450 3A4 system, low bioavailability, and a narrow therapeutic index. Pro...
متن کاملSingle-dose pharmacokinetics of amprenavir coadministered with grapefruit juice.
In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (Cmax) compared to administration with water (7.11 versus 9.10 microg/ml), slightly increased the time to Cmax (1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h...
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B ecause statins markedly reduce cardiovascular risk, poor persistence with them is an important clinical problem. If statins were stopped for valid reasons, there may be no opportunity for improvement. However, there are many invalid reasons why patients stop medication, often for symptoms that, although not causally related, are listed in package inserts. Physicians also stop statin therapy f...
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ژورنال
عنوان ژورنال: The American Journal of Medicine
سال: 2016
ISSN: 0002-9343
DOI: 10.1016/j.amjmed.2016.03.015